Development and evaluation of a Cu(II) complex as nanosuspension for enhanced antitumor efficacy against glioblastoma cancer

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Preparation of CuTW60-NS

The insoluble Cu(II) complex with formula [Cu(2MeObpy)2](PF6)2, where 2MeObpy is 4,4′-dimethoxy-2,2′-bipyridine, was prepared from the reaction of CuCl2∙H2O and 2MeObpy in ethanol in a stoichiometric ratio of 1:2 under stirring condition. The resultant product was purified and characterized according to our previously published method50. The synthesized complex was soluble in organic solvents such as CH3CN, DMF,…



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