Supramolecular polyrotaxane-based nano-theranostics enable cancer-cell stiffening for enhanced T-cell-mediated anticancer immunotherapy

Synthesis and characterization of RDPNs@diABZIs

MeβCD-based supramolecular polyrotaxanes (MSPs) with diselenide-bridged axle polymer by end-capping with two NIR fluorescence probes IR783 (IR783-PEG-MeβCD-PDS) was synthesized, as detailed in the experimental section (Supplementary Fig. 1)^36,37. As a control, MSPs with dicarbonyl-bridged axle polymer by end-capping with two NIR fluorescence probes IR783 (IR783-PEG-MeβCD-PTD) were also…