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(Medical-NewsWire.com, November 13, 2012 ) San Francisco, CA -- One hundred residents of a Sydney, Australia retirement village will take curcumin in supplemental form as part of a clinical trial that recently started there.
Scientists have found that curcumin. The compound is found in the spice turmeric, which is used to make curry. It is a potent antioxidant, superior anti-inflammatory, and may also prevent the onset of Alzheimer’s and other forms of dementia by ridding the body of the protein beta amyloid, which can be found in the part of the brain associated with learning and memory.
"I would liken what amyloid is to Alzheimer's disease to what cholesterol is to heart disease," said Ralph Martins, a professor of ageing and Alzheimer's disease at Edith Cowan University, is conducting the trial with the McCusker Alzheimer's Research Foundation, the Brain and Mind Research Institute and the Royal Prince Alfred Medical Imaging Services. "If you get too much beta amyloid, you get Alzheimer's disease."
According to Martins, most past research has focused on how to treat Alzheimer’s disease once symptoms appear. "What we currently know as clinical Alzheimer's disease is probably the end stage of disease," he said.
"So the disease is cooking in people's brain for as much as 20 years and what we're finding in the healthy normal people is that a third of them will have this toxic amyloid in their brain.There'll be at least 15 years, probably as much as 20 years, before the onset of symptoms, and it's at this stage where the brain is not damaged, so this is where we believe that intervention should be taking place."
Half the retirement village residents will receive curcumin supplements in capsule form, while the other half will receive a placebo. They will all participate in memory tests, MRIs, and brain scans at the beginning of the study and again in one year.
Today there are more than 250,000 Australians with Alzheimer’s, a number expected to grow as baby boomers age. "We have this epidemic, we're talking about 1.1 million people by 2050 or less," Martins said. "For a population as small as ours that's frightening, and this is the only way we're going to put a dent in this epidemic that's going to hit us."
Scientists will not focus solely on curcumin, however. Kathryn Goozee, a dementia consultancy and research manager at the Anglican Retirement Village, and study co-leader said lifestyle choices remain an important factor to consider. "Obviously diet is one thing - we are what we eat," she said."Exercise, social engagement, and stimulating the brain - so cognition, making sure that we're challenging ourselves every day... but the good news if you don't like crossword puzzles, which I'm not particularly fond of, it can be a whole range of different things.
"Sometimes it might be something simple like learning to do a new dance, and that encapsulates the exercise as well as the cognition for new steps as well as the social engagement. So sometimes you can get some triple whammies in as well."
Celebrity chef, author and farmer, Maggie Beer, experienced dementia in her family.
"My own mother died at my age, 67, and you want to protect yourself and those you love and the whole community," she said. "Just think, now that we know these keys, what we can do with children. Their lives could be protected right from the start."
Beer was in Sydney for the study’s start on Thursday to emphasize the importance of a healthy lifestyle but says the antioxidant properties of turmeric surprised her. "I haven't used turmeric a lot, in fact I've hardly ever used it," she said. "But can I tell you, I've just planted it."
Although he acknowledges that India, which has the lowest Alzheimer’s rate in the world, Martins emphasized curry is not enough to protect the brain. "You can do lots of right things but if you a lot of wrong things, you override those benefits," he said.
"Some of those curries in India, especially in Delhi and some of these places - they call it the diabetes capital of the world, for example - their food is extra rich in saturated fats, and saturated fats are pretty bad. Actually, saturated fats tend to increase your amyloid production."
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