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(Medical-NewsWire.com, July 01, 2013 ) Alberta, Canada -- An experimental new nasal spray appears to provide quality dental anesthesia that is considered equivalent to the lidocaine injection currently used by dentists.
The claim comes from a phase-2 trial of the spray type, which was utilized in 45 adults and was published online May 20 and will be again in July in the Journal of Dental Research.
Investigators are completing successful phase-3 trials on the spray and the drug appears likely to receive approval from the US Food and Drug Administration by 2014, according to Sebastian Ciancio, DDS, chair of periodontics and endodontics at the University at Buffalo in New York.
"It could change the whole way people get their dental work done," Dr. Ciancio told Medscape Medical News.
The new approach to anesthesia will appeal to those who avoid dental treatments due to a fear of needles and instruments utilized. The spray is used by otolaryngologists. It combines both oxymetazoline hydrochloride and tetracaine.
For the phase-2 trial, Dr. Ciancio and his colleagues used 45 adults who required 1 maxillary tooth to be restored. The specialists randomly assigned 30 of said patients with the spray and a false injection. The other 15 were given a placebo nasal spray and a lidocaine injection. No subjects were put through having neither.
According to researchers the anesthetic requires 3 doses with 3% tetracaine and 0.05 oxymetazoline hydrochloride at four-minute intervals.
Injections used consisted of 2% lidocaine hydrochloride with 1:100,000 epinephrine within a 1.8-mL cartridge given over the course of 60 seconds. The false injection consisted of a syringe and lidocaine cartridge that had the cap remaining on the tip.
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