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(Medical-NewsWire.com, August 20, 2015 ) Product Synopsis
Multiple Myeloma (MM) is a hematological malignancy characterized by the proliferation of plasma cells in the bone marrow. It is the second-most frequently diagnosed hematological malignancy, with an annual prevalence in the US of about 45,000. The disease is considered incurable, although the past decade has seen significant improvements in therapy, driven by a greater understanding of pathophysiology. Many of the leading drugs in the market were approved over the past 1015 years, and have improved median survival rates by about 50%.
The MM pipeline contains 267 products in active development, encompassing a range of molecule types and therapeutic targets. The innovation that has characterized the market over recent years is also clearly present in the current pipeline, with a strong presence of novel, targeted products.
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Scope
The MM market landscape has undergone significant change over the past two decades.
Which classes of drug have emerged to dominate the market?
What survival benefits have these drugs produced?
How do the leading marketed therapies compare clinically?
The pipeline contains a range of molecule types and molecular targets not present in the current market, including a strong focus on therapies targeting common oncogenic pathways, such as the Phosphoinositide 3-Kinase/Protein Kinase B (PI3K/Akt) pathway.
Which molecular targets appear most frequently in the pipeline?
How will the new therapies be positioned in the treatment of MM?
How have selected late-stage pipeline therapies performed in clinical trials?
MM clinical trials have an overall attrition rate of 78%.
What are the failure rates for individual Phases of clinical development?
How do MM clinical trial characteristics, including failure rate, duration, and size compare against oncology and industry averages?
The MM market is forecast to rise from a value of $7.3 billion in 2014 to $8.9 billion in 2021, at a CAGR of 2.9% across the eight major markets assessed.
How much of a role will disease prevalence and new product approvals play in market growth?
Will generic competition have a significant impact on the market over the forecast period?
There have been 39 licensing deals and 22 co-development deals pertaining to MM products since 2006.
Which territories show the most deal activity?
What were the trends in deal completion by product stage of development?
What were the conditions of the key licensing or co-development deals to take place in MM?
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Reasons to buy
Understand the current clinical and commercial landscape through a comprehensive study of disease pathogenesis, diagnosis, prognosis, and the current treatment algorithm used in MM.
Assess the safety and efficacy of current treatment options, with extensive product profiles on prominent marketed therapies and a heatmap directly comparing safety and efficacy data.
Analyze the MM pipeline and stratify by stage of development, molecule type, and molecular target. The most promising late-stage therapies are profiled and assessed in terms of clinical performance and competitiveness, alongside a single-product forecast.
Predict growth in market size in eight major markets, with in-depth market forecasting from 20142021. The forecasts will provide an understanding of how epidemiology trends, new drug entry, and patent expirations will influence market value.
Identify commercial opportunities in the MM deals landscape by analyzing trends in licensing and co-development deals, and by profiling the most significant deals that have occurred in this indication in recent years.
Table Of Content
1 Table of Contents
1 Table of Contents 4
1.1 List of Tables 6
1.2 List of Figures 7
2 Introduction 9
2.1 Disease Introduction 9
2.2 Etiology 9
2.3 Pathophysiology 9
2.4 Symptoms 11
2.5 Diagnosis and Classification 11
2.6 Epidemiology 14
2.7 Prognosis and Disease Staging 15
2.8 Treatment Options 17
2.8.1 Treatment Algorithm 19
2.8.2 Initial Therapy for Newly Diagnosed Symptomatic Disease 19
2.8.3 Maintenance Therapy 22
2.8.4 Therapy for Relapsed or Refractory Myeloma 24
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3 Marketed Products 29
3.1 Overview 29
3.2 Immunomodulatory Agents 29
3.2.1 Thalomid (thalidomide) Celgene 29
3.2.2 Revlimid (lenalidomide) Celgene 30
3.2.3 Pomalyst (pomalidomide) Celgene 30
3.3 Proteasome Inhibitors 31
3.3.1 Velcade (bortezomib) Millennium Pharmaceuticals/Takeda 31
3.3.2 Kyprolis (carfilzomib) Onyx 31
3.4 Histone Deacetylase Inhibitors 32
3.4.1 Farydak (panobinostat) Novartis 32
3.5 Chemotherapy 32
3.5.1 Doxil (doxorubicin HCl liposome injection) Janssen 32
3.6 Comparative Efficacy and Safety of Marketed Products 33
4 Pipeline Products 38
4.1 Overall Pipeline 38
4.2 Pipeline Analysis by Molecular Target 39
4.3 Clinical Trials 42
4.3.1 Failure Rate 43
4.3.2 Patient Enrolment and Clinical Trial Size 45
4.3.3 Duration 50
4.4 Competitive Clinical Trials Metrics Analysis 51
4.5 Promising Drug Candidates in the Pipeline 53
4.5.1 Ixazomib Citrate Millennium Pharmaceuticals 53
4.5.2 Zolinza (vorinostat) Merck 54
4.5.3 ARRY-520 (filanesib) Array Biopharma 56
4.5.4 Aplidin (plitidepsin) PharmaMar 58
4.5.5 Elotuzumab AbbVie and Bristol Myers Squibb 58
4.5.6 Daratumumab Johnson & Johnson 60
4.6 Heat Map for Pipeline Products 62
5 Market Forecast to 2021 64
5.1 Geographical Markets 64
5.2 Global Market 65
5.3 North America 66
5.3.1 Treatment Usage Patterns 66
5.3.2 Annual Cost of Therapy 67
5.3.3 Market Size 68
5.4 Top Five EU Markets 70
5.4.1 Treatment Usage Patterns 70
5.4.2 Annual Cost of Therapy 71
5.4.3 Market Size 72
5.5 Japan 74
5.5.1 Treatment Usage Patterns 74
5.5.2 Annual Cost of Therapy 74
5.5.3 Market Size 75
5.6 Drivers and Barriers for the Disease Market 76
5.6.1 Drivers 76
5.6.2 Barriers 76
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