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(Medical-NewsWire.com, November 12, 2016 ) Madopar (Parkinsons Disease) - Forecast and Market Analysis to 2022
Summary
Parkinsons disease is a progressive condition that is characterized by bradykinesia, muscular rigidity, tremor, and postural instability. As the second most common neurodegenerative disorder, Parkinsons disease may affect individuals of any age but prevalence is increased with age and it is most common in the elderly. Dopaminergic therapies have been fairly effective in treating bradykinesia, but several unmet needs remain. Some needs will be met during the forecast period from 2012-2022, while others, such as the need for disease-modifying drugs, will remain. GlobalData expects that advancements will be made in levodopa administration and that four new molecular entities will be introduced to the market by 2022, these factors along with increased patient numbers from an aging population will drive the market during the forecast period.
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Madopar is a combination therapy of levodopa with benserazide hydrochloride, a dopamine decarboxylase inhibitor, developed and marketed by Roche. It is used to treat the signs and symptoms of Parkinsons disease, but does not treat the underlying condition. Similar to other levodopa therapies, over time, patients may show reduced responsiveness to Madopar.
Scope
- Overview of Parkinsons disease, including epidemiology, etiology, symptoms, diagnosis, pathology and treatment guidelines as well as an overview on the competitive landscape.
- Detailed information on Madopar including product description, safety and efficacy profiles as well as a SWOT analysis.
- Sales forecast for Madopar for the top seven countries from 2012 to 2022.
- Sales information covered for France, Germany, Italy, Spain, the UK, Japan and Brazil.
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Table of Contents
1 Table of Contents 6
1.1 List of Tables 8
1.2 List of Figures 8
2 Introduction 9
2.1 Catalyst 9
2.2 Related Reports 9
3 Disease Overview 12
3.1 Etiology and Pathophysiology 12
3.1.1 Etiology 12
3.1.2 Pathophysiology 15
3.1.3 Prognosis 17
3.1.4 Quality of Life 18
3.2 Symptoms 18
4 Disease Management 20
4.1 Overview 20
4.1.1 Diagnosis - The UK Brain Bank Criteria 20
4.1.2 Treatment Guidelines and Leading Prescribed Drugs 21
4.2 Treatment Synopsis 24
4.2.1 Dopaminergic Therapy Classes 24
4.2.2 Treatment of Parkinsons Disease by Stage 26
4.2.3 Other Treatment Options 29
4.3 Parkinsons Disease Assessment Scales 29
4.3.1 Unified Parkinsons Disease Rating Scale (UPDRS) 30
4.3.2 Hoehn and Yahr Clinical Staging 32
4.3.3 Other Clinical Assessments 33
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